Obesity is a disease, with obesity patients increasing, obesity-related nephropathy gradually began to be recognized. In 1974, Weisinger first reported the relationship between severe obesity and proteinuria. Subsequent studies have found that glomerular hypertrophy and focal segmental glomerulosclerosis (FSGS) lesions can be observed in renal biopsy patients with obesity-induced proteinuria. Changes in the physiological function of the kidney showed increased renal blood flow and increased glomerular filtration rate.Obesity-related nephropathy is relatively occult. 54.4% of patients with no obvious clinical symptoms, and more in the physical examination found abnormal urine and treatment. Clinical manifestations of proteinuria, mostly light, moderate proteinuria-based, and a large number of proteinuria (> 3.5g / 24h) accounted for only 10.0%. The amount of urinary protein in patients is associated with obesity. In the body mass index ≥ 35kg / m2 patients, the incidence of a large number of proteinuria up to 30.8%. Obesity-related nephropathy in patients with a large number of proteinuria, but low proteinemia is not obvious, showing typical nephrotic syndrome (edema, hypoproteinemia) patients only 2.22%.
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